X-linked myotubular myopathy (XLMTM) is a severe monogenetic disorder of the skeletal muscle.It is caused by loss-of-expression/function mutations in the myotubularin (MTM1) gene.Much of what is known about the disease, as well as the treatment strategies, has been uncovered through experimentation in pre-clinical models, particularly the Mtm1 gene
Protein phosphorylation is one of the main protein post-translational modifications and regulates DNA repair in eukaryotes.Archaeal genomes encode eukaryotic-like DNA repair proteins and protein kinases (ePKs), and several proteins involved in homologous recombination repair (HRR) including Hjc, a conserved Holliday junction (HJ) resolvase in Archa
Objectives: The COVID-19 pandemic had a disruptive impact on tuberculosis (TB) 193x737acg01 and HIV services.We assessed the in-hospital TB diagnostic care among people with HIV (PWH) overall and before and during the pandemic.Methods: In this prospective study, adult PWH admitted at three hospitals in Ghana were recruited if they had a positive Wo
Abstract rowenta dr8270 Background Agitation is a common manifestation of bipolar disorder and schizophrenia which includes symptoms ranging from inner tension and unease to violence and aggression.Much of the existing literature has focused on agitation in the acute setting, with the patient experience poorly defined.Thus, the aim of this study wa
Pharmaceutical and nutritional sciences have recently witnessed a bloom in the scientific literature geared towards the use of food plants for their diversified health benefits and potential clinical applications.Health professionals now recognize that a synergism of drug therapy and nutrition might confer optimum outcomes in the fight against dise